BCL-2 AND IAP Proteins As Potential Drug Targets
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چکیده
منابع مشابه
IAP proteins as targets for drug development in oncology
The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as ...
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Three companies, Genentech, Aegera Therapeutics/Human Genome Sciences, and Novartis, have commenced phase 1 clinical trials of inhibitor of apoptosis (IAP) antagonist 'Smac mimetic' compounds for the treatment of cancer. These trials represent the culmination of a line of research that commenced with analysis of how insect viruses stop host cells from killing themselves and led to the discovery...
متن کاملGlycosyltransferases as Potential Drug Targets
Copyright: © 2013 Sun XL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Glycoconjugates, existing as glycoproteins, glycolipids and proteoglycans on cell surface, are involved in many biological processes, s...
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Intrinsically disordered proteins (IDPs) are characterized by a lack of folded structure. Since their identification more than a decade ago, they were designed as potential drug targets. However, nowadays, only few therapeutic molecules have been designed against them. Due to the nature of these proteins bioinformatics methods could have a key role disentangling IDPs related issues, which is ke...
متن کامل[Structural and functional studies on proteins as potential drug discovery targets].
Structural biology teaches us about the fundamental nature of biological molecules. Drug design is the most immediate medical application of structural biology. Therefore our studies have been focused on structural and functional studies of human disease-related proteins and proteins essential for the growth and development of pathogenic organisms. The present paper describes 1) structural biol...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2001
ISSN: 1537-744X
DOI: 10.1100/tsw.2001.129